Programme

Day one (25th Sep) : Theory  & practice 

9.00–9.15 Welcome address
9.15–10.45  Hybrid modeling methods  1 (Introduction to hybrid modeling; Hybrid model structures; Identification methods; Indirect identification; sensitivities method; parameter estimation; cross-validation), Dr. Moritz v. Stosch and Prof. R. Oliveira
10.45-11.00  Coffee Break
11.00–12.30 Hybrid modeling methods  2  -  The general bioreactor hybrid model;  Deriving a bioreactor hybrid model for Escherichia coli, Dr. Moritz v. Stosch and Prof. R. Oliveira
12.30–13:30 Lunch
13.30–14.30 Introduction to the hybrid modeling toolbox,  Dr. Mark Dürkop
14.30–16.15 Hands on Hybrid modeling 1, Dr. Moritz v. Stosch, Dr. Mark Dürkop, MSc. José Pinto
16.15-16.45 Coffee Break
16.45–18.15 Hands on Hybrid modeling 2, Dr. Moritz v. Stosch, Dr. Mark Dürkop, MSc. José Pinto
19.30 Dinner and networking

 

Day two (26th Sep):  Theory & practice

9.00–10.30 Hybrid modeling methods 3 : Direct identification method; pruning methods hybrid model discrimination; bootstrap aggregation; prediction confidence intervals;  Dr. Moritz v. Stosch and Prof. R. Oliveira
10.30-10.45 Coffee Break
10.45–12.15 Hybrid model quality monitoring by the experience measure method; Dynamic optimization – optimal control method constrained by hybrid model reliability. Dr. Moritz v. Stosch and Prof. R. Oliveira
12.15–13.15 Lunch
13.15–14.30 Participants pitching their work
14.30–17.00 Hands on Hybrid modeling  3, Dr. Moritz v. Stosch, Dr. Mark Dürkop, MSc. José Pinto
17.00-17.30 Coffee Break
17.30–18.15 Industrial applications of hybrid modeling, Dr. Thomas Mrziglod (Bayer)
19.30 Sponsor Dinner


Day three (27th Sep): Advanced applications

9.00-9.30 Hybrid modeling for QbD and PAT (to be confirmed)
9.30–10.00 Title to be anounced,  Dr. Thomas Mrziglod (Bayer)
10.00-10.30 Towards model predictive control of CHO cultures, Dr. Wolfgang Sommeregger, Bilfinger AG
10.30–11.00 Coffee Break
11.00–11.30 Hybrid modeling for culture media optimization, Prof. Rui Oliveira, FCTUNL
11.30–12:00 Data management in the industry 4.0, Martin Mayer, Eppendorf AG
12.00–12.30  Risk & Knowledge Management: Supporting Operational Excellence over Lifecycle in Biopharma Operations, Prof José C Menezes, IST
12.30–13.30 Lunch
13.30-14.00 Scale-up of a reaction step from lab to commercial scale, switching from batch to continuous manufacturing using a mechanistic modelling approach, Dr. Filipe Ataide, Hovione SA
14.00–14.30 Using Hybrid Modeling and Intensified Design of Experiments  to Reduce Bioprocess Development and Characterization Times, Dr. Mark Dürkop, BOKU University
14.30–15.00 Assembling an end-to-end framework for training, validation and deployment of hybrid models, Dr. Mafred Mücke,  Materials Center Leoben GmbH
15:00-15.30 Coffee Break
15.30-16.00 Applications of Hybrid Models for Downstream Processes: a Tangencial Flow Filtration Case Study, MSc Maximilian Krippl, BOKU University
16.00-16.30 To be confirmed
16.30-17.30 “Hybrid modeling in the industry 4.0” Panel Discussion & Closing Ceremony