A toolbox approach to biopharmaceutical protein purification using unconventional and non-chromatography unit operations

As we continue to improve our understanding of the complexity, diversity and broad base of human disease, the nature of the biopharmaceutical drug candidates being developed and applied to such diseases expands. This presentation will explore a Contract Manufacture and Development Organisation’s (CDMO) toolbox approach to the purification of proteins derived from both mammalian and microbial expression systems. The toolbox comprises a range of unit operations including both unconventional and non-chromatography unit operations and explores a number of modes of operation such as connected- and continuous-purification.  All the techniques described are suitable for operation in a highly regulated Good Manufacturing Practice (GMP) environment and fully scalable to generate drug product for use in clinical trials or commercial applications.