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Jose Artur Brito graduated in Biotechnological Engineering in 2001 and after a short training period at the University of Madison Wisconsin (USA) he joined the Macromolecular Crystallography Lab at ITQB NOVA. After his Ph.D. degree in 2011, Jose took a joint postdoctoral position with the Membrane Protein Crystallography and the Bacterial Cell Biology labs at ITQB NOVA and in 2018, he became co-Principal Investigator of the Membrane Protein Crystallography Laboratory.

Jose’s work lies on the interface between Biochemistry and Biophysics, with a special emphasis on Structural Biology techniques. His Team is interested in exploring alternative metabolic pathways in pathogenic bacteria, namely, hydrogen sulfide synthesis and degradation, thiosulfate/tetrathionate interconversions, and RNA homeostasis, as promising drug targets for new antibiotics. Jose has been studying some of the proteins from these pathways that might present as potential novel drug targets, which can, in turn, be used to tackle antibiotic resistance.

Title of talk: Structural and functional insights into hydrogen sulfide homeostasis in pathogenic bacteria